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Arquivos Brasileiros de Cardiologia

Print version ISSN 0066-782XOn-line version ISSN 1678-4170

Abstract

TEIXEIRA, Ricardo Alkmim et al. Cardiac Damage from Chronic Use of Chloroquine: A Case Report and Review of the Literature. Arq. Bras. Cardiol. [online]. 2002, vol.79, n.1, pp.85-88. ISSN 0066-782X.  http://dx.doi.org/10.1590/S0066-782X2002001000009.

Chloroquine has been widely used in rheumatological treatment, but potential severe side effects require careful follow-up. Cardiac damage is not a common consequence, but its clinical relevance has not yet been described. We report the case of a 58-year-old woman with rheumatoid arthritis, in whom chronic chloroquine use resulted in major irreversible cardiac damage. She presented with syncopal episodes due to complete atrioventricular block confirmed by electrophysiological study whose changes were concluded to be irreversible and a permanent pacemaker was indicated. Endomyocardial biopsy was also performed to search for histopathological and ultrastructural cardiac damage. We also reviewed the 22 cases of chloroquine-induced cardiopathy described to date as well as its pathophysiology.

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