Abstract

SILVA, Claudia Cristina Soares et al. Blood pressure, metabolic and autonomic responses to insulin and intralipid^® infusion in chagasic patients. Arq. Bras. Cardiol. [online]. 2012, vol.98, n.3, pp. 225-233.  Epub Feb 29, 2012. ISSN 0066-782X.  http://dx.doi.org/10.1590/S0066-782X2012005000018.

BACKGROUND: Intralipid and heparin infusion results in increased blood pressure and autonomic abnormalities in normal and hypertensive individuals. OBJECTIVE: To evaluate insulin sensitivity and the impact of Intralipid and heparin (ILH) infusion on hemodynamic, metabolic, and autonomic response in patients with the indeterminate form of Chagas' disease. METHODS: Twelve patients with the indeterminate form of Chagas' disease and 12 healthy volunteers were evaluated. RESULTS: Baseline blood pressure and heart rate were similar in both groups. Plasma noradrenaline levels were slightly increased in the Chagas' group. After insulin tolerance testing (ITT), a significant decline was noted in glucose in both groups. ILH infusion resulted in increased blood pressure in both groups, but there was no significant change in plasma noradrenaline. The low-frequency component (LF) was similar and similarly increased in both groups. The high-frequency component (HF) was lower in the Chagas' group. CONCLUSION: Patients with the indeterminate form of Chagas' disease had increased sympathetic activity at baseline and impaired response to insulin. They also had a lower high-frequency component and impaired baroreflex sensitivity at baseline and during Intralipid and heparin infusion.

Keywords : Chagas disease; insulin [adverse effects]; fat emulsions; intravenous [pharmacology]; blood pressure.