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Arquivos Brasileiros de Cardiologia
Print version ISSN 0066-782X
MILOVANOVIC, Milena et al. Vitamin d deficiency is associated with increased il-17 and tnfα levels in patients with chronic heart failure. Arq. Bras. Cardiol. [online]. 2012, vol.98, n.3, pp.259-265. Epub Feb 29, 2012. ISSN 0066-782X. http://dx.doi.org/10.1590/S0066-782X2012005000019.
BACKGROUND: Recent studies revealed a strong association between vitamin D (VD) status and chronic heart failure (CHF). It is now commonly considered that proinflammatory immune response underlies CHF development. OBJECTIVE: Since VD expresses anti-inflammatory properties, we investigated its impact on cytokines implicated in CHF, such as TNFα and IL-17, in patients suffering from CHF. METHODS: Blood was obtained from forty patients with CHF secondary to hypertension and/or coronary heart disease. VD status, IL-17 and TNFαlevels were assessed using 25-hydroxy VD3 EIA and cytokine ELISAs. Clinical assessment and echocardiography was also performed. RESULTS: Elderly patients with CHF in Nis (Southeast Europe, latitude 43ºN) exhibited 25-hydroxy VD3 levels below normal. Our data identified that patients with CHF secondary to hypertension have significantly lower 25-hydroxy VD3, increased TNFα and IL-17A levels in comparison to donors with CHF secondary to coronary disease. CONCLUSION: This study reveals that even in regions with a lot of sunny days VD deficiency represents a concerning issue. Data suggest that impaired VD status contributes to high IL-17 and TNFα levels and thereby may support CHF development.
Keywords : Vitamin D deficiency; heart failure; interleukin-17; hypertension.