SciELO - Scientific Electronic Library Online

 
vol.98 issue3Use of fluorescence in a modified disector method to estimate the number of myocytes in cardiac tissueMultislice coronary angiotomography in the assessment of coronary artery anomalous origin author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Arquivos Brasileiros de Cardiologia

Print version ISSN 0066-782X

Abstract

MILOVANOVIC, Milena et al. Vitamin d deficiency is associated with increased il-17 and tnfα levels in patients with chronic heart failure. Arq. Bras. Cardiol. [online]. 2012, vol.98, n.3, pp. 259-265.  Epub Feb 29, 2012. ISSN 0066-782X.  http://dx.doi.org/10.1590/S0066-782X2012005000019.

BACKGROUND: Recent studies revealed a strong association between vitamin D (VD) status and chronic heart failure (CHF). It is now commonly considered that proinflammatory immune response underlies CHF development. OBJECTIVE: Since VD expresses anti-inflammatory properties, we investigated its impact on cytokines implicated in CHF, such as TNFα and IL-17, in patients suffering from CHF. METHODS: Blood was obtained from forty patients with CHF secondary to hypertension and/or coronary heart disease. VD status, IL-17 and TNFαlevels were assessed using 25-hydroxy VD3 EIA and cytokine ELISAs. Clinical assessment and echocardiography was also performed. RESULTS: Elderly patients with CHF in Nis (Southeast Europe, latitude 43ºN) exhibited 25-hydroxy VD3 levels below normal. Our data identified that patients with CHF secondary to hypertension have significantly lower 25-hydroxy VD3, increased TNFα and IL-17A levels in comparison to donors with CHF secondary to coronary disease. CONCLUSION: This study reveals that even in regions with a lot of sunny days VD deficiency represents a concerning issue. Data suggest that impaired VD status contributes to high IL-17 and TNFα levels and thereby may support CHF development.

Keywords : Vitamin D deficiency; heart failure; interleukin-17; hypertension.

        · abstract in Portuguese | Spanish     · text in English | Portuguese | Spanish     · pdf in English | Spanish | Portuguese