Memórias do Instituto Oswaldo Cruz
Print version ISSN 0074-0276
On-line version ISSN 1678-8060
GUERREIRO, Jaqueline et al. Bacterial infection in patients with visceral leishmaniasis. Mem. Inst. Oswaldo Cruz [online]. 1985, vol.80, n.4, pp.447-452. ISSN 0074-0276. http://dx.doi.org/10.1590/S0074-02761985000400011.
In an analysis of 63 hospitalized cases with visceral leishmaniasis, the clinical or post-mortem diagnosis of bacterial infection was performed in 33; 13 (39.3%) patients had respiratory infection, 4 (12.1%) had skin infection, 4 had urinary tract infection, 3 (9.0%) showed ear infection and 2 (6.6%) had infection of the oral cavity. It is worth mentioning that in 7 (21%) cases there was infection in multiple sites. Gram positive and/or Gram negative organisms were isolated from 10 patients. In only two (autopsied) cases, infection with less common organisms was recorded, one with disseminated candidiasis and another with disseminated tuberculosis. Death occurred in 9 of the 63 cases, and in 8 of these, concomitant bacterial infection of importance was documented. Patients who had serum globulins lower than 4 g% had significantly more infection (p less than 0.05) than patients with globulin levels higher than 4 g%; there was no significant difference when the number of leucocytes and neutrophils in patients with associated infection was compared with those in patients without bacterial infection. The present study demonstrates that bacterial infection frequently occurs in patients with visceral leishmaniasis, and indicates an unfavourable prognosis. Even though the mechanism of increased susceptibility to infection in this condition was unclear, the widespread range of infections and of infective agents, suggests a multifactorial process.
Keywords : infecção bacteriana; complicações da leishmaniose visceral; infecções em leishmaniose visceral; susceptibilidade a infecções em leishmaniose visceral.