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vol.85 issue2Experimental chagas' disease in rhesus monkeys. I. Clinical parasitological, hematological and anatomo-pathological studies in the acute and indeterminate phase of the diseaseTrypanosoma nupelianus sp. n. (Protozoa, Kinetoplastida) parasitizing rhinelepis aspera (Osteichthyes, Loricariidae) from Paraná river, Brazil author indexsubject indexarticles search
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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276

Abstract

MEIRELLES, Maria de Nazareth Leal de; BONECINI-ALMEIDA, Maria da Glória; PESSOA, Maria Heleosina Ribeiro  and  GALVAO-CASTRO, Bernardo. Trypanosoma cruzi: experimental Chagas' disease in Rhesus monkeys. II. Ultraestructural and cytochemical studies of peroxidase and acid phosphatase activities. Mem. Inst. Oswaldo Cruz [online]. 1990, vol.85, n.2, pp. 173-181. ISSN 0074-0276.  http://dx.doi.org/10.1590/S0074-02761990000200005.

Ultrastructural and cytochemical studies of peroxidase and acid phosphatase were performed in skin, lymph node and heart muscle tissue of thesus monkeys with experimental Chagas's disease. At the site of inoculation ther was a proliferative reaction with the presence of immature macrophages revealed by peroxidase technique. At the lymph node a difuse inflammatory exudate with mononuclear cells, fibroblasts and immature activated macrophages reproduces the human patrtern of acute Chagas' disease inflamatory lesions. The hearth muscle cells present different degrees of degenerative alterations and a striking increase in the number of lysosomal profiles that exhibit acid hydrolase reaction product. A strong inflammatory reaction was present due to lymphocytic infiltrate or due to eosinophil granulocytes associated to ruptured cells. The present study provides some experimental evidences that the monkey model could be used as a reliable model to characterize histopathological alterations of the human disease.

Keywords : ultrastructural cytochemistry; peroxidase activity; acid phosphatase; Chagas' disease; rhesus monkeys.

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