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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060


Markers, Cofactors and Staging Systems in the Study of HIV Disease Progression: A Review. Mem. Inst. Oswaldo Cruz [online]. 1997, vol.92, n.4, pp.437-457. ISSN 0074-0276.

This paper is aimed at providing a comprehensive review of markers, cofactors and staging systems used for HIV disease, focusing on some aspects that nowadays could even be considered historical, and advancing in current issues such as the prognostic value of viral load measurements, viral genotypic and phenotypic characterization, and new HIV disease treatment protocols. CD4+ cell values, combined with the new viral markers mentioned are promising as a parsimonious predictor set for defining both severity and progression. An adequate predictor of patient resource use for planning purposes still needs to be defined

Keywords : HIV disease progression; markers; cofactors; staging systems; AIDS classification systems.

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