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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060


GOTTLIEB, Otto R  and  BORIN, Maria Renata de MB. Medicinal products: regulation of biosynthesis in space and time . Mem. Inst. Oswaldo Cruz [online]. 2000, vol.95, n.1, pp.115-120. ISSN 0074-0276.

We live in a "Demon-Haunted World". Human health care requires the ever increasing resistance of pathogens to be confronted by a correspondingly fast rate of discovery of novel antibiotics. One of the possible strategies towards this objective involves the rational localization of bioactive phytochemicals. The conceptual basis of the method consists in the surprisingly little known gearings of natural products with morphology, ecology and evolution of their plant source, i. e. an introspection into the general mechanisms of nature.

Keywords : quantitative chemical biology; metabolism; morphology; ecology; evolution.

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