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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Abstract

VIEIRA, MGS et al. B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases. Mem. Inst. Oswaldo Cruz [online]. 2002, vol.97, n.7, pp.979-983. ISSN 0074-0276.  http://dx.doi.org/10.1590/S0074-02762002000700009.

Biopsies from human localized cutaneous lesions (LCL n = 7) or disseminated lesions (DL n = 8) cases were characterized according to cellular infiltration,frequency of cytokine (IFN-g, TNF-a) or iNOS enzyme producing cells. LCL, the most usual form of the disease with usually one or two lesions, exhibits extensive tissue damage. DL is a rare form with widespread lesions throughout the body; exhibiting poor parasite containment but less tissue damage. We demonstrated that LCL lesions exhibit higher frequency of B lymphocytes and a higher intensity of IFN-g expression. In both forms of the disease CD8+ were found in higher frequency than CD4+ T cells. Frequency of TNF-a and iNOS producing cells, as well as the frequency of CD68+ macrophages, did not differ between LCL and DL. Our findings reinforce the link between an efficient control of parasite and tissue damage, implicating higher frequency of IFN-g producing cells, as well as its possible counteraction by infiltrated B cells and hence possible humoral immune response in situ.

Keywords : leishmaniasis; B lymphocytes; cytokines; CD8+ T cells; IFN-g.

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