Abstract

MIAGOSTOVICH, Marize Pereira et al. Complete genetic characterization of a Brazilian dengue virus type 3 strain isolated from a fatal outcome. Mem. Inst. Oswaldo Cruz [online]. 2006, vol.101, n.3, pp. 307-313. ISSN 0074-0276.  http://dx.doi.org/10.1590/S0074-02762006000300015.

We have determined the complete nucleotide and the deduced amino acid sequences of Brazilian dengue virus type 3 (DENV-3) from a dengue case with fatal outcome, which occurred during an epidemic in the state of Rio de Janeiro, Brazil, in 2002. This constitutes the first complete genetic characterization of a Brazilian DENV-3 strain since its introduction into the country in 2001. DENV-3 was responsible for the most severe dengue epidemic in the state, based on the highest number of reported cases and on the severity of clinical manifestations and deaths reported.

Keywords : dengue virus type 3; complete genome; Brazil.