SciELO - Scientific Electronic Library Online

 
vol.101 issue5Evolution and pathology in Chagas disease: a reviewApplication of biochemical and polymerase chain reaction assays for identification of Campylobacter isolates from non-human primates author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Abstract

OLIVEIRA, Ana Carla Pozzi et al. Antifungal activity of propolis extract against yeasts isolated from onychomycosis lesions. Mem. Inst. Oswaldo Cruz [online]. 2006, vol.101, n.5, pp.493-497. ISSN 0074-0276.  http://dx.doi.org/10.1590/S0074-02762006000500002.

The aim of this study was to determine the in vitro activity of propolis extract against 67 yeasts isolated from onychomycosis in patients attending at the Teaching and Research Laboratory of Clinical Analysis of the State University of Maringá. The method used was an adaptation made from the protocol approved by the National Committee for Clinical Laboratory Standards. The yeasts tested were: Candida parapsilosis 35%, C. tropicalis 23%, C. albicans 13%, and other species 29%. The propolis extract showed excellent performance regarding its antifungal activity: the concentration capable of inhibiting the all of the yeasts was 5 ´ 10-2 mg/ml of flavonoids and 2 ´ 10-2 mg/ml of flavonoids stimulated their cellular death. Trichosporon sp. were the most sensitive species, showing MIC50 and MIC90 of 1.25 ´ 10-2 mg/ml of flavonoids, and C. tropicalis was the most resistant, with CFM50 of 5 ´ 10-2 mg/ml of flavonoids and MFC90 of 10 ´ 10-2 mg/ml. In view of the fact that propolis is a natural, low cost, non-toxic product with proven antifungal activity, it should be considered as another option in the onychomycosis treatment.

Keywords : propolis; flavonoids; antifungal activity; yeasts; onychomycosis.

        · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License