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Memórias do Instituto Oswaldo Cruz

On-line version ISSN 1678-8060

Abstract

NINO, Jaime; HERNANDEZ, Jimmy A; CORREA, Yaned M  and  MOSQUERA, Oscar M. In vitro inhibition of acetylcholinesterase by crude plant extracts from Colombian flora. Mem. Inst. Oswaldo Cruz [online]. 2006, vol.101, n.7, pp. 783-785. ISSN 1678-8060.  http://dx.doi.org/10.1590/S0074-02762006000700013.

The methanol extracts from five different plant families (Asteraceae, Euphorbiaceae, Melastomataceae, Rubiaceae, and Solanaceae) collected at Regional Natural Park Ucumarí (Colombia), were screened for their acetylcholinesterase inhibitory activity through the modified Ellman's spectrophotometric method. The best inhibitory activities on this study were shown by the extracts of Solanum leucocarpum Dunal (IC50 = 204.59 mg/l) and Witheringia coccoloboides (Damm) (IC50 = 220.68 mg/l), both plants belonging to the Solanaceae family.

Keywords : acetylcholinesterase (AChE) inhibitors; Asteraceae; Euphorbiaceae; Melastomataceae; Rubiaceae; Solanaceae.

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