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vol.101 suppl.1Clinical-epidemiological profile of children with schistosomal myeloradiculopathy attended at the Instituto Materno-Infantil de PernambucoProduction of full-length cDNA sequences by sequencing and analysis of expressed sequence tags from Schistosoma mansoni author indexsubject indexarticles search
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Print version ISSN 0074-0276On-line version ISSN 1678-8060


SILVA, SH et al. Characterization of the gene expression related to the process of DNA damage tolerance in Schistosoma mansoni. Mem. Inst. Oswaldo Cruz [online]. 2006, vol.101, suppl.1, pp.157-160. ISSN 0074-0276.

In the course of its complex life cycle, the parasite Schistosoma mansoni need to adapt to distinct environments, and consequently is exposed to various DNA damaging agents. The Schistosoma genome sequencing initiative has uncovered sequences from genes and transcripts related to the process of DNA damage tolerance as the enzymes UBC13, MMS2, and RAD6. In the present work, we evaluate the importance of this process in different stages of the life cycle of this parasite. The importance is evidenced by expression and phylogenetic profiles, which show the conservation of this pathway from protozoa to mammalians on evolution.

Keywords : Schistosoma mansoni; ubiquitin conjugating enzymes; DNA damage tolerance.

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