Memórias do Instituto Oswaldo Cruz
Print version ISSN 0074-0276
On-line version ISSN 1678-8060
ARAUJO, Josélio Maria Galvão de et al. Dengue virus type 3 in Brazil: a phylogenetic perspective. Mem. Inst. Oswaldo Cruz [online]. 2009, vol.104, n.3, pp.526-529. ISSN 0074-0276. http://dx.doi.org/10.1590/S0074-02762009000300021.
Circulation of a new dengue virus (DENV)-3 genotype was recently described in Brazil and Colombia, but the precise classification of this genotype has been controversial. Here we perform phylogenetic and nucleotide-distance analyses of the envelope gene, which support the subdivision of DENV-3 strains into five distinct genotypes (GI to GV) and confirm the classification of the new South American genotype as GV. The extremely low genetic distances between Brazilian GV strains and the prototype Philippines/L11423 GV strain isolated in 1956 raise important questions regarding the origin of GV in South America.
Keywords : dengue virus type 3; genotypes; Brazil.