Memórias do Instituto Oswaldo Cruz
Print version ISSN 0074-0276
OLIVEIRA, Gabriel Melo de et al. Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection. Mem. Inst. Oswaldo Cruz [online]. 2009, vol.104, n.8, pp.1063-1071. ISSN 0074-0276. http://dx.doi.org/10.1590/S0074-02762009000800002.
Trypanosoma cruzi infection induces diverse alterations in immunocompetent cells and organs, myocarditis and congestive heart failure. However, the physiological network of disturbances imposed by the infection has not been addressed thoroughly. Regarding myocarditis induced by the infection, we observed in our previous work that Fas-L-/- mice (gld/gld) have very mild inflammatory infiltration when compared to BALB/c mice. However, all mice from both lineages die in the early acute phase. Therefore, in this work we studied the physiological connection relating arterial pressure, renal function/damage and cardiac insufficiency as causes of death. Our results show that a broader set of dysfunctions that could be classified as a cardio/anaemic/renal syndrome is more likely responsible for cardiac failure and death in both lineages. However, gld/gld mice had very early glomerular deposition of IgM and a more intense renal inflammatory response with reduced renal filtration, which is probably responsible for the premature death in the absence of significant myocarditis in gld/gld.
Keywords : Trypanosoma cruzi; Fas-L; myocarditis; acute kidney injury.