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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276

Abstract

RABONI, Sonia Mara et al. Molecular epidemiology of HIV-1 clades in Southern Brazil. Mem. Inst. Oswaldo Cruz [online]. 2010, vol.105, n.8, pp.1044-1049. ISSN 0074-0276.  https://doi.org/10.1590/S0074-02762010000800015.

Human immunodeficiency virus (HIV) clades B and C account for more than 60% of the HIV-1 infections worldwide. In this paper, we describe the profiles of patients infected with subtypes of HIV-1 from the state of Paraná, Southern Brazil, and correlate them with demographic and epidemiological findings. A retrospective analysis of HIV cases reported from 1999-2007 was also performed. Data from 293 patients were reviewed and 245 were older than 13 (58% female). The distribution of clades was as follows: B 140 (57%), C 67 (23%), F 24 (10%) and mosaic or unique recombinant forms (URFs) 24 (10%). Of the 48 patients younger than 13 years of age (62.5% male), vertical transmission occurred in 46 and the distribution of clades was as follows: B 14 (29%), C 24 (50%), F 7 (15%) and URFs 6 (13%). There was no significant difference in mortality between HIV-1 subtypes. In both groups, patients infected with clade C tended to have higher rates of injection drug use exposure risk.

Keywords : HIV; subtypes; genetic variability; HIV exposure.

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