Memórias do Instituto Oswaldo Cruz
Print version ISSN 0074-0276
DUSFOUR, Isabelle et al. Multiple insecticide resistance in Aedes aegypti (Diptera: Culicidae) populations compromises the effectiveness of dengue vector control in French Guiana. Mem. Inst. Oswaldo Cruz [online]. 2011, vol.106, n.3, pp. 346-352. ISSN 0074-0276. http://dx.doi.org/10.1590/S0074-02762011000300015.
In French Guiana, pyrethroids and organophosphates have been used for many years against Aedes aegypti. We aimed to establish both the resistance level of Ae. aegypti and the ultra low volume spray efficacy to provide mosquito control services with practical information to implement vector control and resistance management. Resistance to deltamethrin and fenitrothion was observed. In addition, the profound loss of efficacy of AquaK'othrine® and the moderate loss of efficacy of Paluthion® 500 were recorded. Fenitrothion remained the most effective candidate for spatial application in French Guiana until its removal in December 2010. Further investigation of the mechanism of resistance to deltamethrin demonstrated the involvement of mixed-function oxidases and, to a lesser extent, of carboxylesterases. However, these observations alone cannot explain the level of insecticide resistance we observed during tube and cage tests.
Keywords : Aedes aegypti; insecticide resistance; vector control; French Guiana.