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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276


JABLONKA, Willy et al. A transient increase in total head phosphotyrosine levels is observed upon the emergence of Aedes aegypti from the pupal stage. Mem. Inst. Oswaldo Cruz [online]. 2011, vol.106, n.5, pp.546-552. ISSN 0074-0276.

Phosphorylation and dephosphorylation of protein tyrosine residues constitutes a major biochemical regulatory mechanism for the cell. We report a transient increase in the total tyrosine phosphorylation of the Aedes aegypti head during the first days after emergence from the pupal stage. This correlates with an initial reduction in total head protein tyrosine phosphatase (PTP) activity. Similarly, phosphotyrosine (pTyr)-containing bands are seen in extracts prepared from both male and female heads and are spread among a variety of structures including the antennae, proboscis and the maxillary palps combined with the proboscis. Also, mosquitoes treated with sodium orthovanadate, a classical PTP inhibitor, show reduced blood-feeding activity and higher head tyrosine phosphorylation levels. These results suggest that pTyr-mediated signalling pathways may play a role in the initial days following the emergence of the adult mosquito from the pupal stage.

Keywords : Aedes aegypti; tyrosine phosphorylation; blood-feeding.

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