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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276

Abstract

DIAS, Alyria Teixeira et al. Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis. Mem. Inst. Oswaldo Cruz [online]. 2011, vol.106, n.5, pp. 617-619. ISSN 0074-0276.  http://dx.doi.org/10.1590/S0074-02762011000500015.

The presence of intestinal helminths can down-regulate the immune response required to control mycobacterial infection. BALB/c mice infected with Mycobacterium bovis following an infection with the intestinal helminth Strongyloides venezuelensis showed reduced interleukin-17A production by lung cells and increased bacterial burden. Also, small granulomas and a high accumulation of cells expressing the inhibitory molecule CTLA-4 were observed in the lung. These data suggest that intestinal helminth infection could have a detrimental effect on the control of tuberculosis (TB) and render coinfected individuals more susceptible to the development of TB.

Keywords : M. bovis; S. venezuelensis; coinfection; IL-17; CTLA-4; - tuberculosis.

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