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Memórias do Instituto Oswaldo Cruz

versión impresa ISSN 0074-0276versión On-line ISSN 1678-8060

Resumen

CARVALHO, Leonardo José de Moura; MOREIRA, Aline da Silva; DANIEL-RIBEIRO, Cláudio Tadeu  y  MARTINS, Yuri Chaves. Vascular dysfunction as a target for adjuvant therapy in cerebral malaria. Mem. Inst. Oswaldo Cruz [online]. 2014, vol.109, n.5, pp.577-588. ISSN 0074-0276.  http://dx.doi.org/10.1590/0074-0276140061.

Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum malaria that continues to be a major global health problem. Brain vascular dysfunction is a main factor underlying the pathogenesis of CM and can be a target for the development of adjuvant therapies for the disease. Vascular occlusion by parasitised red blood cells and vasoconstriction/vascular dysfunction results in impaired cerebral blood flow, ischaemia, hypoxia, acidosis and death. In this review, we discuss the mechanisms of vascular dysfunction in CM and the roles of low nitric oxide bioavailability, high levels of endothelin-1 and dysfunction of the angiopoietin-Tie2 axis. We also discuss the usefulness and relevance of the murine experimental model of CM by Plasmodium berghei ANKA to identify mechanisms of disease and to screen potential therapeutic interventions.

Palabras clave : cerebral malaria; vascular dysfunction; nitric oxide.

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