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Memórias do Instituto Oswaldo Cruz

versión impresa ISSN 0074-0276versión On-line ISSN 1678-8060

Resumen

SOUSA, Taís Nóbrega de; KANO, Flora Satiko; BRITO, Cristiana Ferreira Alves de  y  CARVALHO, Luzia Helena. The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon. Mem. Inst. Oswaldo Cruz [online]. 2014, vol.109, n.5, pp.608-617. ISSN 0074-0276.  https://doi.org/10.1590/0074-0276130592.

Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania.

Palabras clave : malaria; Plasmodium vivax; Duffy binding protein; naturally acquired antibodies; genetic variability.

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