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vol.109 número5Plasmodium simium/Plasmodium vivax infections in southern brown howler monkeys from the Atlantic ForestThe remarkable journey of adaptation of the Plasmodium falciparum malaria parasite to New World anopheline mosquitoes índice de autoresíndice de materiabúsqueda de artículos
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Memórias do Instituto Oswaldo Cruz

versión impresa ISSN 0074-0276versión On-line ISSN 1678-8060


SMITH, Ryan C; VEGA-RODRIGUEZ, Joel  y  JACOBS-LORENA, Marcelo. The Plasmodium bottleneck: malaria parasite losses in the mosquito vector. Mem. Inst. Oswaldo Cruz [online]. 2014, vol.109, n.5, pp.644-661. ISSN 0074-0276.

Nearly one million people are killed every year by the malaria parasite Plasmodium. Although the disease-causing forms of the parasite exist only in the human blood, mosquitoes of the genus Anopheles are the obligate vector for transmission. Here, we review the parasite life cycle in the vector and highlight the human and mosquito contributions that limit malaria parasite development in the mosquito host. We address parasite killing in its mosquito host and bottlenecks in parasite numbers that might guide intervention strategies to prevent transmission.

Palabras clave : malaria; mosquito; Plasmodium; innate; immunity.

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