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Memórias do Instituto Oswaldo Cruz

versão impressa ISSN 0074-0276


LIONE, Viviane de Oliveira Freitas et al. Interferon-γ inhibits group B Streptococcus survival within human endothelial cells. Mem. Inst. Oswaldo Cruz [online]. 2014, vol.109, n.7, pp.940-943.  Epub 28-Out-2014. ISSN 0074-0276.

Endothelial dysfunction is a major component of the pathophysiology of septicaemic group B Streptococcus (GBS) infections. Although cytokines have been shown to activate human umbilical vein endothelial cells (HUVECs), the capacity of interferon (IFN)-γ to enhance the microbicidal activity of HUVECs against GBS has not been studied. We report that the viability of intracellular bacteria was reduced in HUVECs activated by IFN-γ. Enhanced fusion of lysosomes with bacteria-containing vacuoles was observed by acid phosphatase and the colocalisation of Rab-5, Rab-7 and lysosomal-associated membrane protein-1 with GBS in IFN-γ-activated HUVECs. IFN-γ resulted in an enhancement of the phagosome maturation process in HUVECs, improving the capacity to control the intracellular survival of GBS.

Palavras-chave : group B Streptococcus; IFN-γ; survival.

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