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Memórias do Instituto Oswaldo Cruz

versão impressa ISSN 0074-0276


BARBIERI, Raquel Rodrigues et al. Diagnostic challenges of single plaque-like lesion paucibacillary leprosy. Mem. Inst. Oswaldo Cruz [online]. 2014, vol.109, n.7, pp.944-947.  Epub 14-Out-2014. ISSN 0074-0276.

The diagnosis of single-lesion paucibacillary leprosy remains a challenge. Reviews by expert dermatopathologists and quantitative polymerase chain reaction (qPCR) results obtained from 66 single-plaque biopsy samples were compared. Histological findings were graded as high (HP), medium (MP) or low (LP) probability of leprosy or other dermatopathy (OD). Mycobacterium leprae-specific genes were detected using qPCR. The biopsies of 47 out of 57 clinically diagnosed patients who received multidrug therapy were classified as HP/MP, eight of which were qPCR negative. In the LP/OD (n = 19), two out of eight untreated patients showed positive qPCR results. In the absence of typical histopathological features, qPCR may be utilised to aid in final patient diagnosis, thus reducing overtreatment and delay in diagnosis.

Palavras-chave : paucibacillary leprosy; diagnosis; quantitative polymerase chain reaction.

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