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Memórias do Instituto Oswaldo Cruz

versão impressa ISSN 0074-0276


ANDRADE, Bruno Gabriel N et al. Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil. Mem. Inst. Oswaldo Cruz [online]. 2014, vol.109, n.7, pp.972-974. ISSN 0074-0276.

There has been a resurgence in the number of pertussis cases in Brazil and around the world. Here, the genome of a clinical Bordetella pertussis strain (Bz181) that was recently isolated in Brazil is reported. Analysis of the virulence-associated genes defining the pre- and post-vaccination lineages revealed the presence of the prn2-ptxS1A-fim3B-ptxP3 allelic profile in Bz181, which is characteristic of the current pandemic lineage. A putative metallo-β-lactamase gene presenting all of the conserved zinc-binding motifs that characterise the catalytic site was identified, in addition to a multidrug efflux pump of the RND family that could confer resistance to erythromycin, which is the antibiotic of choice for treating pertussis disease.

Palavras-chave : ptxP3; pandemic lineage; virulence factors; antigenic variant.

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