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Memórias do Instituto Oswaldo Cruz

versão impressa ISSN 0074-0276versão On-line ISSN 1678-8060

Resumo

LAVORATO, Stefânia Neiva et al. In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures. Mem. Inst. Oswaldo Cruz [online]. 2015, vol.110, n.4, pp.566-568.  Epub 29-Maio-2015. ISSN 0074-0276.  http://dx.doi.org/10.1590/0074-02760150007.

We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytotoxicity tests against L929 cells, only compound 4 presented selectivity index value above 10, indicating low toxicity.

Palavras-chave : Trypanosoma cruzi; antitrypanosomal agents; Chagas disease; 1,3-bisaryloxypropanamines.

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