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Memórias do Instituto Oswaldo Cruz

versão impressa ISSN 0074-0276versão On-line ISSN 1678-8060

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PEREIRA, Polyana Silva; ALBANO, Rodolpho Mattos; ASENSI, Marise Dutra  e  CARVALHO-ASSEF, Ana Paula D’Alincourt. Draft genome sequences of three NDM-1-producing Enterobacteriaceae species isolated from Brazil. Mem. Inst. Oswaldo Cruz [online]. 2015, vol.110, n.4, pp.580-582.  Epub 29-Maio-2015. ISSN 0074-0276.  http://dx.doi.org/10.1590/0074-02760150081.

The emergence of multidrug-resistant Enterobacteriaceae strains producing carbapenemases, such as NDM-1, has become a major public health issue due to a high dissemination capacity and limited treatment options. Here we describe the draft genome of three NDM-1-producing isolates: Providencia rettgeri(CCBH11880), Enterobacter hormaecheisubsp. oharae(CCBH10892) and Klebsiella pneumoniae(CCBH13327), isolated in Brazil. BesidesblaNDM-1, resistance genes to aminoglycosides [aadA1, aadA2,aac(6’)-Ib-cr] and quinolones (qnrA1,qnrB4) were observed which contributed to the multidrug resistance profile. The element ISAba125 was found associated to theblaNDM-1 gene in all strains.

Palavras-chave : NDM-1; Brazil; Enterobacteriaceae.

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