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vol.113 número7Advances in Cryptococcus genomics: insights into the evolution of pathogenesis índice de autoresíndice de assuntospesquisa de artigos
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Memórias do Instituto Oswaldo Cruz

versão impressa ISSN 0074-0276versão On-line ISSN 1678-8060

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JANBON, Guilhem. Introns in Cryptococcus. Mem. Inst. Oswaldo Cruz [online]. 2018, vol.113, n.7, e170519.  Epub 19-Fev-2018. ISSN 0074-0276.  http://dx.doi.org/10.1590/0074-02760170519.

In Cryptococcus neoformans, nearly all genes are interrupted by small introns. In recent years, genome annotation and genetic analysis have illuminated the major roles these introns play in the biology of this pathogenic yeast. Introns are necessary for gene expression and alternative splicing can regulate gene expression in response to environmental cues. In addition, recent studies have revealed that C. neoformans introns help to prevent transposon dissemination and protect genome integrity. These characteristics of cryptococcal introns are probably not unique to Cryptococcus, and this yeast likely can be considered as a model for intron-related studies in fungi.

Palavras-chave : intron; Cryptococcus; RNA; yeast; alternative splicing.

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