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Memórias do Instituto Oswaldo Cruz

versão impressa ISSN 0074-0276versão On-line ISSN 1678-8060


GARELNABI, Mariam  e  MAY, Robin C. Variability in innate host immune responses to cryptococcosis. Mem. Inst. Oswaldo Cruz [online]. 2018, vol.113, n.7, e180060.  Epub 16-Abr-2018. ISSN 0074-0276.

Cryptococcosis is an invasive fungal disease caused by Cryptococcus neoformans and the closely related species C. gattii. The severe form of the disease, cryptococcal meningitis (CM), is rapidly fatal without treatment. Although typically a disease of immunocompromised (especially HIV-positive) individuals, there is growing awareness of cryptococcal disease amongst non-immunocompromised patients. Whilst substantial progress has been made in understanding the pathogenicity of C. neoformans in HIV patients, prospective data on cryptococcosis outside the context of HIV remains lacking. Below we review how innate immune responses vary between hosts depending on immunological status, and discuss risk factors and predictors of disease outcome in different groups.

Palavras-chave : Cryptococcus neoformans; host-pathogen interactions; innate immunity; infection; pathogenesis; macrophages; host variation.

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