SciELO - Scientific Electronic Library Online

 
vol.114Tuberculosis-HIV treatment with rifampicin or rifabutin: are the outcomes different?Immunogenicity and safety of the combined vaccine for measles, mumps, and rubella isolated or combined with the varicella component administered at 3-month intervals: randomised study author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Abstract

NUNES, Renata Rachide et al. Brazilian malaria molecular targets (BraMMT): selected receptors for virtual high-throughput screening experiments. Mem. Inst. Oswaldo Cruz [online]. 2019, vol.114, e180465.  Epub Feb 25, 2019. ISSN 0074-0276.  http://dx.doi.org/10.1590/0074-02760180465.

BACKGROUND

Owing to increased spending on pharmaceuticals since 2010, discussions about rising costs for the development of new medical technologies have been focused on the pharmaceutical industry. Computational techniques have been developed to reduce costs associated with new drug development. Among these techniques, virtual high-throughput screening (vHTS) can contribute to the drug discovery process by providing tools to search for new drugs with the ability to bind a specific molecular target.

OBJECTIVES

In this context, Brazilian malaria molecular targets (BraMMT) was generated to execute vHTS experiments on selected molecular targets of Plasmodium falciparum.

METHODS

In this study, 35 molecular targets of P. falciparum were built and evaluated against known antimalarial compounds.

FINDINGS

As a result, it could predict the correct molecular target of market drugs, such as artemisinin. In addition, our findings suggested a new pharmacological mechanism for quinine, which includes inhibition of falcipain-II and a potential new antimalarial candidate, clioquinol.

MAIN CONCLUSIONS

The BraMMT is available to perform vHTS experiments using OCTOPUS or Raccoon software to improve the search for new antimalarial compounds. It can be retrieved from www.drugdiscovery.com.br or download of Supplementary data.

Keywords : docking; virtual screening; structure based drug design and bioinformatics.

        · text in English     · English ( pdf )