SciELO - Scientific Electronic Library Online

 
vol.46 issue2People with vascular ulcers in outpatient nursing care: a study of sociodemographic and clinical variablesAssessing the risk of falls for the elderly in Basic Health Units author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Revista da Escola de Enfermagem da USP

Print version ISSN 0080-6234

Abstract

MONTEIRO, Cintia et al. Hydrogen potential of antibiotic solutions subjected to environmental conditions: a preliminary trial. Rev. esc. enferm. USP [online]. 2012, vol.46, n.2, pp. 311-319. ISSN 0080-6234.  http://dx.doi.org/10.1590/S0080-62342012000200007.

This experimental study was performed to assess the hydrogen potential (pH) of the antimicrobials ceftriaxone sodium, vancomycin hydrochloride, metronidazole, penicillin G potassium, and amikacin sulphate, following reconstitution, diluted with NaCl 0.9% (SF) and glucose solution 5% (GS), at eight different time intervals and under the normal daily conditions of lighting and temperature within the hospital unit (no air conditioning). The objective of this study was to verify the changes in the acid-base behavior of the solutions, which indicate chemical instability and can be associated with complications during intravenous therapy. Of the 186 analyzed pH values, there were no variations greater than 1.0 and no physical alterations visible to the naked eye. All solutions had a pH less than 7, and there were no significant differences for clinical practice regarding the diluent. The mean pH values after dilution with SF and GS for vancomycin hydrochloride, metronidazole, and amikacin sulphate are a risk factor for the development of intravenous complications due to their extreme acidity.

Keywords : Hidrogen-Ion concentration; Drug stability; Infusions; intravenous; Medication errors; Pediatric nursing.

        · abstract in Portuguese | Spanish     · text in English | Portuguese     · pdf in Portuguese