Mucinous carcinoma of the breast: iconographic essay with histopathological correlation

The present essay is aimed at describing the most characteristic imaging findings of mucinous carcinoma of the breast, with emphasis on the patterns related to better prognosis. The authors selected cases of mucinous carcinoma of the breast whose images were available, highlighting the imaging findings suggestive of this subtype of breast cancer, either at mammography, ultrasonography or magnetic resonance imaging.

Breast neoplasm; Mucinous carcinoma; Mammography; Ultrasonography; Magnetic resonance imaging

Authorship

Gustavo Nunes Medina Coeli

Radiologists, MDs, Residents at Centro de Ciências das Imagens e Física Médica - Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HC-FMRPUSP)Universidade de São PauloBrazilRibeirão Preto, SP, BrazilRadiologists, MDs, Residents at Centro de Ciências das Imagens e Física Médica - Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HC-FMRPUSP)

Henrique Ferreira dos Reis

Dayse Ribeiro Bertinetti

Francesca Maia Faria

Pathologist, Physician Assistant, Department of Pathology, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRPUSP)Universidade de São PauloBrazilRibeirão Preto, SP, BrazilPathologist, Physician Assistant, Department of Pathology, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRPUSP)

Daniel Guimarães Tiezzi

PhD, Professor, Department of Gynecology and Obstetrics, Mastology Division, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRPUSP)Universidade de São PauloBrazilRibeirão Preto, SP, BrazilPhD, Professor, Department of Gynecology and Obstetrics, Mastology Division, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRPUSP)

Tatiane Mendes Gonçalves de Oliveira

MD, Radiologist, Centro de Ciências das Imagens e Física Médica - Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HC-FMRPUSP)Universidade de São PauloBrazilRibeirão Preto, SP, BrazilMD, Radiologist, Centro de Ciências das Imagens e Física Médica - Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HC-FMRPUSP)

Mailing Address: Dr. Gustavo Nunes Medina Coeli. Avenida Anna Cardoso de Miranda, 185, Jardim Inconfidência. Uberlândia, MG, Brazil, 38411-231. E-mail: gustavonmc@yahoo.com.br.

SCIMAGO INSTITUTIONS RANKINGS

Figures

Figures (5)

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Figure 1.
A: Female, 69-year-old patient. Craniocaudal view demonstrating nodule with microlobulated margins in the medial quadrant of the right breast, diagnosed as pure MMC. B: Histological section of the lesion, identifying mucinous tumor with neoplastic cells involved by moderate amount of extracellular mucin.

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Figure 2.
A: Female, 69-year-old patient with pure MMC, with typical sonographic findings: ovoid and microlobulated nodule, isoechoic to fat tissue and with posterior acoustic enhancement. B: Female, 58-year-old patient with an ovoid nodule with indistinct and angulated margins, with no noticeable microlobulation, with posterior acoustic enhancement, diagnosed as mixed MMC. C: Histology from this patient demonstrating mucinous neoplasia with peripheral DCIS foci at left.

Thumbnail

Figure 3.
Female, 32-year-old patient with pure MMC. A: Mediolateral, oblique mammographic view demonstrating microlobulated ovoid nodule at the junction of the medial quadrants of the right breast. B: Axial MRI STIR image of the described nodule, demonstrating intense hypersignal onT2-weighted sequence with hypointense septa, common findings in mucinous carcinomas. C: Histological section at microscopy identifying mucinous tumor with a remarkable amount of mucin and little cellularity. D,E: Dynamic contrast-enhanced, T1-weighted images with fat suppression and subtraction, at the second and fifth minutes, demonstrating predominantly ring-shaped and progressive enhancement, and also marked enhancement of the septa within the lesion. F: Sagittal 3D reconstruction.

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Figure 4.
Female, 54-year-old patient with anatomopathological diagnosis of pure MMC. A: Sagittal T2-weighted SPAIR image demonstrating lobulated lesion with high signal on T2-weighted sequence. Color mapping of wash-in (B) and kinetic curve (C) showing slight enhancement at the early phase with progressive enhancement pattern.

Thumbnail

Figure 5.
Female, 54-year-old patient with pure mucinous tumor represented on diffusion-weighted images, with b value = 0 on A and b = 700 on B, revealing minimum restriction, corroborated by the high signal intensity on C (ADC map).

Figure 1. A: Female, 69-year-old patient. Craniocaudal view demonstrating nodule with microlobulated margins in the medial quadrant of the right breast, diagnosed as pure MMC. B: Histological section of the lesion, identifying mucinous tumor with neoplastic cells involved by moderate amount of extracellular mucin.

Figure 2. A: Female, 69-year-old patient with pure MMC, with typical sonographic findings: ovoid and microlobulated nodule, isoechoic to fat tissue and with posterior acoustic enhancement. B: Female, 58-year-old patient with an ovoid nodule with indistinct and angulated margins, with no noticeable microlobulation, with posterior acoustic enhancement, diagnosed as mixed MMC. C: Histology from this patient demonstrating mucinous neoplasia with peripheral DCIS foci at left.

Figure 3. Female, 32-year-old patient with pure MMC. A: Mediolateral, oblique mammographic view demonstrating microlobulated ovoid nodule at the junction of the medial quadrants of the right breast. B: Axial MRI STIR image of the described nodule, demonstrating intense hypersignal onT2-weighted sequence with hypointense septa, common findings in mucinous carcinomas. C: Histological section at microscopy identifying mucinous tumor with a remarkable amount of mucin and little cellularity. D,E: Dynamic contrast-enhanced, T1-weighted images with fat suppression and subtraction, at the second and fifth minutes, demonstrating predominantly ring-shaped and progressive enhancement, and also marked enhancement of the septa within the lesion. F: Sagittal 3D reconstruction.

Figure 4. Female, 54-year-old patient with anatomopathological diagnosis of pure MMC. A: Sagittal T2-weighted SPAIR image demonstrating lobulated lesion with high signal on T2-weighted sequence. Color mapping of wash-in (B) and kinetic curve (C) showing slight enhancement at the early phase with progressive enhancement pattern.

Figure 5. Female, 54-year-old patient with pure mucinous tumor represented on diffusion-weighted images, with b value = 0 on A and b = 700 on B, revealing minimum restriction, corroborated by the high signal intensity on C (ADC map).

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