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SIQUEIRA, João Máximo de et al. Activity - guided isolation of constituents of Unonopsis lindmanii - Annonaceae, based on the brine shrimp lethality bioassay. Quím. Nova [online]. 1998, vol.21, n.5, pp.557-559. ISSN 0100-4042. http://dx.doi.org/10.1590/S0100-40421998000500004.
Extracts obtained from leaves, seeds and bark of Unonopsis lindmanii were evaluated by means of Brine Shrimp Lethality test (BSL). Through bioassay-guided chromatographic fractionation, liriodenine, an oxoaporphine alkaloid, was isolated from the bark extracts as the bioactive compound. Two additional inactive known alkaloids, unonopsine and lysicamine were also isolated from the bark extracts.
Keywords : Annonaceae; Artemia salina; oxoaporphinic alkaloids; liriodenine; unonopsine; lysicamine.