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On-line version ISSN 1678-7064
ANDRICOPULO, Adriano Defini et al. Synthesis and antibacterial activity of cyclic imides: 3,4 dichloromaleimides and 3-chloro-4-substituted-maleimides. Quím. Nova [online]. 1998, vol.21, n.5, pp. 573-577. ISSN 1678-7064. http://dx.doi.org/10.1590/S0100-40421998000500008.
In the present study, new N-aryl and N-alkylarylcyclic imides were synthesized and their antibacterial properties against Escherichia coli and Staphylococcus aureus were evaluated by using the diffusion method. All compounds were obtained in good yield (54 - 95%) and characterized by spectral data (1H-NMR, MS, IR) and elemental analysis (CHN). The biological results indicated that some compounds exert significative antibacterial effects, confirming previous studies on biological activities of cyclic imides.
Keywords : cyclic imides; antibacterial activity; cyclic imido double bond.