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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064

Abstract

REINA, Luisa del Carmen Barrett et al. On the interaction of organosulfur compounds from garlic with cytochrome-c: an eletrochemical study. Quím. Nova [online]. 2002, vol.25, n.1, pp.5-9. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422002000100002.

Organosulfur compounds present in garlic and onion have been evaluated as inhibitors of chemical carcinogenesis. Among them diallylsulfide was mainly investigated and studies demonstrated its metabolization to the corresponding sulfoxide and sulfone. In this work, we report the investigation of the interaction between the diallylsulfide and its oxidized derivatives, through cyclic voltammetry, with horse heart cytocrome-c (on a modified electrode with 4-mercaptopyridine). Our results suggest that there is a reversible interaction between cytocrome-c and diallylsulfide and diallylsulfone and an irreversible interaction with the diallylsulfoxide.

Keywords : diallylsulfide derivatives; cyclic voltammetry; cytochrome-c.

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