SciELO - Scientific Electronic Library Online

vol.25 issue1Molybdenum disulfide, a multifunctional and remarkable materialAspects related to the use of the quadratic logistic equation in electrochemical processes author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064


SOUZA, Marcus .V. N. de  and  ALMEIDA, Mauro V. de. The ortho metalation reaction in pyridines. Quím. Nova [online]. 2002, vol.25, n.1, pp.89-98. ISSN 0100-4042.

In this paper we describe a powerful methodology for the regiospecific construction of polysubstituted aromatic and heteroaromatic compounds. The DoM reaction (direct ortho-metalation) comprises the deprotonation in position ortho of a aromatic or heteroaromatic containing DMG (directed metalation group) by strong bases, normally an alkyllithium reagent, leading to an ortho-lithiated species. These species, upon treatment with electrophilic reagents, gives 1,2 disubstituted products.

Keywords : ortho-metalation; directed metallation group; heteroaromatic compounds.

        · text in Portuguese     · Portuguese ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License