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Química Nova

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DONNICI, Claudio Luis; OLIVEIRA, Ione Maria Ferreira de; TEMBA, Eliane Sílvia Codo  and  CASTRO, Maurício Costa Rogério de. Synthetic methods for preparation of substituted 2,2'-bipyridines. Quím. Nova [online]. 2002, vol.25, n.4, pp.668-675. ISSN 0100-4042.

The 2,2'-bipyridine has been entitled as the most widely used ligand. Nowadays there is a large variety of known molecules comprising at least two 2,2'-bipyridine units and the number of applications in many areas such as catalysis, new materials, optoeletronics and electrochemistry have increased very much in the past decades. Nevertheless, there is no article that gives an overview of the main synthetic methods for obtaining the substituted 2,2'-bipyridines, generally non available. This article presents a synthetic discussion about the three different methods (coupling reaction, ciclo-functionalization and functionalization of the heteroaromatic rings of 2,2'-bipyridine) for preparing these heterocyclic compounds and also provides a practical and fundamental guide, for obtaining more than eighty different symmetric and unsymmetrical substituted 2,2'-bipyridines, shown in a table with the corresponding references.

Keywords : 2,2'-bipyridines; synthesis; coupling; functionalization.

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