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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064


ALMEIDA, Mauro Vieira de; SILVA, Adilson David da; SOUZA, Marcus Vinícius Nora de  and  BENICIO, Aloísio Antônio Alves. The phosphoinositide cascate. Quím. Nova [online]. 2003, vol.26, n.1, pp.105-111. ISSN 0100-4042.

Inositol is a polyalcohol required for the proper formation of cell membranes. In the body, its plays an important role in the transmission of nerve impulses, its also helps in the transporting of fats within the body. In mammals, inositol exists as phosphorylated derivatives, various phosphoinositides, and in its free form. Agonist stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is the first step in the transmembrane signalling mechanism when cells respond to external stimuli. Under control of activated phospholipase C (PLC) via G-protein, two second messengers D-myo-inositol 1,4,5-triphosphate [Ins(1,4,5)P3] and diacylglycerol are released into the cell. From Ins(1,4,5)P3, enzymatic process under phosphatases or kinases control affords subsequent inositol phosphate metabolites. During the last decade the synthesis of modified inositol phosphate derivatives has been strongly investigated. This paper reviews principal aspects about synthesis and biological functions of these biomolecules.

Keywords : second messengers; phosphoinositides; inositol phosphate.

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