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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064


MOREIRA, Fátima R.  and  MOREIRA, Josino C.. The significance of lead speciation analysis in blood plasma for health risk assessment. Quím. Nova [online]. 2004, vol.27, n.2, pp.251-260. ISSN 0100-4042.

Lead absorption is influenced by the species that are formed and the physicochemical characteristics of lead, among others. Lead plasma concentration is < 5% of total blood lead and represents the biologically active fraction able to cross the cell membranes. Health risks mainly depend on a specific metal and its species. Speciation analysis is the analytical activity of identifying and determining different metal species. Chromatographic methods are very useful in the identification of species and the techniques most used to determine metals in biological fluids are ICP OES/MS and AAS. Lead speciation analysis in blood plasma is fundamental for understanding and evaluating the interaction mechanisms between that analyte and its biological targets.

Keywords : lead; plasma; speciation analysis.

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