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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064

Abstract

NEVES, Gilda; RATES, Stela M. K.; FRAGA, Carlos A. M.  and  BARREIRO, Eliezer J.. Dopaminergic agents and erectile dysfunction treatment. Quím. Nova [online]. 2004, vol.27, n.6, pp.949-957. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422004000600020.

The understanding of the scientific basis of the erectile function expanded rapidly the range of therapies for treating erectile dysfunction in recent years. This article reviews the role of dopamine on the erection mechanisms and its importance for new pro-erectile drug design. The ability of dopaminergic agents to elicit penile erection has been described since 1975 and successively confirmed by numerous studies. The development of apomorphine SL (dopaminergic non selective agonist) to enhance erectile function represents a new pharmacological approach to the management of erectile dysfunction using CNS drugs. The search for selective D4 dopaminergic agents is being explored by some research groups and pharmaceutical companies.

Keywords : erectile dysfunction; dopaminergic agents; apomorphine.

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