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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064


ALMEIDA, Vera Lúcia de et al. Cancer and cell cicle-specific and cell cicle nonspecific anticancer DNA-interactive agents: an introduction. Quím. Nova [online]. 2005, vol.28, n.1, pp.118-129. ISSN 0100-4042.

The chemotherapy agents against cancer may be classified as "cell cycle-specific" or "cell cycle-nonspecific". Nevertheless, several of them have their biological activity related to any kind of action on DNA such as: antimetabolic agents (DNA synthesis inhibition), inherently reactive agents (DNA alkylating electrophilic traps for macromolecular nucleophiles from DNA through inter-strand cross-linking - ISC - alkylation) and intercalating agents (drug-DNA interactions inherent to the binding made due to the agent penetration in to the minor groove of the double helix). The earliest and perhaps most extensively studied and most heavily employed clinical anticancer agents in use today are the DNA inter-strand cross-linking agents.

Keywords : anticancer agents; cycle-(non-)specific agents; DNA inter-strand cross-linking (ISC agents).

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