Resumen

GASPAROTTO JR., Arquimedes et al. Phytochemical study and evaluation of the molluscicidal activity of Calophyllum brasiliense Camb (Clusiaceae). Quím. Nova [online]. 2005, vol.28, n.4, pp.575-578. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422005000400003.

The bioassay-guided fractionation against Biomphalaria glabrata of hydroalcoholic extracts of Calophyllum brasiliense aerial parts led to the isolation of the coumarin, named (-) mammea A/BB. The compound had its structure determined by both spectroscopic techniques (NMR ¹H, NMR ¹³C, gHSQC, gHMBC and MS) and some literature comparison data. The probit analysis of (-) mammea A/BB showed LD₅₀ = 0.67 ppm and LD₉₀ = 1.47 ppm. In addition, the dichloromethane extract obtained from C. brasiliense leaves with significant molluscicidal activity against Biomphalaria glabrata was analyzed by HPLC-UV.

Palabras clave : Calophyllum brasiliense; molluscicidal activity; coumarin.

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