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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064

Abstract

BONATO, Pierina Sueli; JABOR, Valquíria Aparecida Polisel  and  GAITANI, Cristiane Masetto de. Enantioselective analysis of drugs: contributions of high-performance liquid chromatography and capillary electrophoresis. Quím. Nova [online]. 2005, vol.28, n.4, pp.683-691. ISSN 0100-4042.  https://doi.org/10.1590/S0100-40422005000400023.

The demand for analytical methods suitable for accurate and reproducible determination of drug enantiomers has increased significantly in the last years. High-performance liquid chromatography (HPLC) using chiral stationary phases and capillary electrophoresis (CE) are the most important techniques used for this purpose. In this paper, the fundamental aspects of chiral separations using both techniques are presented. Some important aspects for the development of enantioselective methods, particularly for the analysis of drugs and metabolites in biological samples, are also discussed.

Keywords : chiral drugs; high-performance liquid chromatography; capillary electrophoresis.

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