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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064


AZEVEDO, Mariangela S. et al. A novel synthesis of a-bromoacetophenones and its application in obtaining 2-benzoylbenzofuranes. Quím. Nova [online]. 2006, vol.29, n.6, pp.1259-1265. ISSN 0100-4042.

a-Bromoacetophenones are important in organic synthesis. They have been widely used as precursors of several natural products. Several methods of bromination aiming at their synthesis have been described, however they furnish a mixture of starting material 10, mono 8 and dibromide 11 products. We developed a novel, simple and efficient synthesis of these compounds with applications in the synthesis of benzoylbenzofurans 9, compounds with important pharmacological properties, such as the ability of dilating the coronary artery and analgesic action. Such compounds have also been used as key intermediates to obtain quinone systems.

Keywords : a-bromoacetophenones; benzoylbenzofurans; phenyltrimethylammonium tribromide.

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