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Química Nova

versão impressa ISSN 0100-4042

Resumo

BLAU, Lorena; MENEGON, Renato Farina  e  CHUNG, Man Chin. Prodrug activation by enzyme, a promising strategy for chemotherapy. Quím. Nova [online]. 2006, vol.29, n.6, pp. 1307-1317. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422006000600028.

Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives.

Palavras-chave : prodrugs; enzymes; cancer.

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