versão On-line ISSN 1678-7064
BLAU, Lorena; MENEGON, Renato Farina e CHUNG, Man Chin. Prodrug activation by enzyme, a promising strategy for chemotherapy. Quím. Nova [online]. 2006, vol.29, n.6, pp. 1307-1317. ISSN 1678-7064. http://dx.doi.org/10.1590/S0100-40422006000600028.
Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives.
Palavras-chave : prodrugs; enzymes; cancer.