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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064

Abstract

SANTOS, Viviane Martins Rebello dos; DONNICI, Claudio Luis; DACOSTA, João Batista Neves  and  CAIXEIRO, Janaína Marques Rodrigues. Organophosphorus pentavalent compounds: history, synthetic methods of preparation and application as insecticides and antitumor agents. Quím. Nova [online]. 2007, vol.30, n.1, pp.159-170. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422007000100028.

This paper is a review of the history, synthesis and application of organophosphorus compounds, especially of those of pentavalent phosphorus, such as phosphoramidates, phosphorothioates, phosphonates and phosphonic acids with insecticide and anticancer activities. The organophosphorus compounds with agrochemical applications show great structural variety, They include not only insecticides, but also fungicides, herbicides, and others. The large variety of commercially available organophosphorus pesticides is remarkable. Even more interesting is the high efficiency of some organophosphorus compounds as anticancer agents such as cyclophosphamide and its derivatives.

Keywords : organophosphorus compounds; insecticides; anticancer agents.

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