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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064

Abstract

OLIVEIRA, Renata B. de et al. Synthesis, biological evaluation and molecular modeling of arylfurans as potential trypanothione reductase inhibitors. Quím. Nova [online]. 2008, vol.31, n.2, pp.261-267. ISSN 0100-4042.  https://doi.org/10.1590/S0100-40422008000200013.

Trypanosoma cruzi is a protozoan parasite that causes a severe disease (Chagas'disease) in Central and South America. The currently available chemotherapeutic agents against this disease are still inadequate. The enzyme trypanothione reductase (TR) is considered a validated molecular target for the development of new drugs against this parasite. In this regard, a series of arylfurans based on 2,5-bis-(4-acetamidophenyl)furan was synthesized and tested for their in vitro inhibitory activity against TR. Molecular modeling studies of putative enzyme-inhibitor complexes revealed a possible mechanism of interaction. From synthesized compounds, a benzylaminofuran derivative was found to be more active than the lead compound.

Keywords : trypanothione reductase; molecular modeling; arylfurans.

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