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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064

Abstract

GRILLO, Renato et al. Physico-chemical characterization of inclusion complex between hydroxymethylnitrofurazone and hydroxypropyl-b-cyclodextrin. Quím. Nova [online]. 2008, vol.31, n.2, pp.290-295. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422008000200019.

Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-b-cyclodextrin (HP-b-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-b-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (DGº= 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment.

Keywords : hydroxymethylnitrofurazone; cyclodextrin; inclusion complex.

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