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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064


MANFRINI, Rozângela Magalhães et al. Synthesis of aryl b-N-acetylglucosaminedes modified at C-6 as potential antimicrovial agents. Quím. Nova [online]. 2008, vol.31, n.2, pp.326-329. ISSN 0100-4042.

We report herein the synthesis of aryl b-N-acetylglucosaminides containing azido, amino and acetamido groups at C-6 as potential antimicrobial agents. It was expected that these compounds could interfere with the biosynthesis and/or biotransformation of N-acetylglucosamine in fungi and bacteria. None of the compounds showed antimicrobial activity against bacteria (Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa), filamentous fungus (Aspergillus niger) and yeasts (Saccharomyces cerevisae, Candida albicans and Candida tropicallis), at the concentration of 1 mg/mL in agar diffusion assay.

Keywords : N-acetylglucosamine derivatives; antimicrobial activity.

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