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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064

Abstract

LIESEN, André P. et al. Preparation methods, reactivity and biological importance of 4-thiazolidinones. Quím. Nova [online]. 2008, vol.31, n.2, pp.369-376. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422008000200033.

Molecules containing the 4-thiazolidinone ring are known to possess a wide range of biological properties including antimicrobial and anti-inflammatory activities among others. These compounds can be synthesized by cyclization reactions involving a-haloacetic acid or a-mercaptoacetic acid and employed in several chemoselective reactions. Comprehensive reviews have been written on 4-thiazolidinones in 1961 by Brown and in 1980 by Singh et al. In the recent literature, some new synthesis methods for 4-thiazolidinone derivatives and several reactions have been reported. These advances warrant to review the chemical and biological properties of compounds with this important heterocycle employed in synthetic organic chemistry and medicinal chemistry.

Keywords : 4-thiazolidinone; preparation methods; reactivity.

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