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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064


RIVERA, Gildardo et al. An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine. Quím. Nova [online]. 2008, vol.31, n.3, pp.536-538. ISSN 0100-4042.

We have developed an easy method for the synthesis of thirteen compounds derived from 1,2,4-triazoles through a carboxylic acid and hydrazinophthalazine reaction, with a 75-85% yield mediated by the use of agents such as 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide hydrochloride and 1-hydroxybenzotriazole. The operational simplicity of this method and the good yield of products make it valuable for the synthesis of new compounds with pharmacological activity.

Keywords : 1,2,4-triazoles; carboxylic acids; hydrazinophthalazine.

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